Upstream Bio Inc.
Organization details
- Legal name
- Upstream Bio Inc.
- Ownership
- Public
- Status
- Active
- Sector (GICS)
- Health Care
- SIC code
- 2834 — Pharmaceutical Preparations
- Jurisdiction of incorporation
- Delaware
- Headquarters city
- Waltham
- Headquarters state / province
- Massachusetts
- Headquarters country
- United States
- Fiscal year end
- December
- Ticker symbol
- UPB
- Primary stock exchange
- Nasdaq
Identifiers
- SEC CIK
- 0002022626
Board of directors
-
Daniella Beckman · DirectorSince 2024
-
Erez Chimovits · DirectorSince 2024
-
Everett Rand Sutherland · Director · Chief Executive OfficerSince 2024
-
Harold Edward Fleming · DirectorSince 2024
-
Liam Ratcliffe · DirectorSince 2024
-
Marcella K. Ruddy · DirectorSince 2024
-
Ronald C. Renaud Jr. · DirectorSince 2024
Chief executives
Strong · grade B
Out of 100, from shareholder return, dividends, growth and acquisitions.
Partial: only 20% of the scoring weight is on file.
- Revenue growth 20%
- 78
9.5% a year in revenue
20% of the scoring weight is on file. Figures cover December 2023 – December 2025.
Director election results
Annual meeting of June 9, 2026. Support is votes for as a share of votes for and against (or withheld). Below 80% is a clear protest.
-
92.4%
Board connections
7 of this board's directors also sit on 11 other boards. 11 are in the same sector.
-
Sionna Therapeutics Inc. Same sectorvia Harold Edward Fleming and Marcella K. Ruddy
-
ADARx Pharmaceuticals Inc. Same sectorvia Erez Chimovits
-
Adicet Bio Inc. Same sectorvia Erez Chimovits
-
Braveheart Bio Inc. Same sectorvia Erez Chimovits
-
CRISPR Therapeutics AG Same sectorvia Harold Edward Fleming
-
Climb Bio Inc. Same sectorvia Liam Ratcliffe
-
Disc Medicine Inc. Same sectorvia Liam Ratcliffe
-
Kailera Therapeutics Inc. Same sectorvia Ronald C. Renaud Jr.
-
Krystal Biotech Inc. Same sectorvia Everett Rand Sutherland
-
OnKure Therapeutics Inc. Same sectorvia Liam Ratcliffe
-
Vor Biopharma Inc. Same sectorvia Daniella Beckman
Insider trades
All notable trades →From SEC Forms 4 and 5. Open-market purchases and sales are highlighted; grants, option exercises and shares withheld for tax are routine.
- Bought, last 12 months
- $0
- 0 purchases by 0 insiders
- Sold, last 12 months
- $104,796
- 15 sales by 5 insiders
| Date | Insider | Transaction | Shares | Price | Value |
|---|---|---|---|---|---|
| Sep 16, 2026 | Ambrose Allison Officer (General Counsel) | Open-market sale | −485 | $5.49 | $2,663 |
| Sep 16, 2026 | Deykin Aaron Officer (Chief Medical Officer) | Open-market sale | −895 | $5.49 | $4,914 |
| Sep 16, 2026 | GRAY MICHAEL Officer (CFO and COO) | Open-market sale | −853 | $5.49 | $4,683 |
| Sep 16, 2026 | Houghton Adam Officer (Chief Business Officer) | Open-market sale | −700 | $5.49 | $3,843 |
| Sep 16, 2026 | Everett Rand Sutherland Director, Officer (Chief Executive Officer) | Open-market sale | −2,095 | $5.49 | $11,502 |
| Jun 16, 2026 | GRAY MICHAEL Officer (CFO and COO) | Open-market sale | −853 | $6.10 | $5,203 |
| Jun 16, 2026 | Everett Rand Sutherland Director, Officer (Chief Executive Officer) | Open-market sale | −2,095 | $6.10 | $12,780 |
| Jun 16, 2026 | Houghton Adam Officer (Chief Business Officer) | Open-market sale | −700 | $6.10 | $4,270 |
| Jun 16, 2026 | Deykin Aaron Officer (Chief Medical Officer) | Open-market sale | −895 | $6.10 | $5,460 |
| Jun 16, 2026 | Ambrose Allison Officer (General Counsel) | Open-market sale | −477 | $6.10 | $2,910 |
| Mar 16, 2026 | GRAY MICHAEL Officer (CFO and COO) | Open-market sale | −852 | $9.29 | $7,915 |
| Mar 16, 2026 | Deykin Aaron Officer (Chief Medical Officer) | Open-market sale | −894 | $9.29 | $8,305 |
| Mar 16, 2026 | Everett Rand Sutherland Director, Officer (Chief Executive Officer) | Open-market sale | −2,093 | $9.29 | $19,444 |
| Mar 16, 2026 | Ambrose Allison Officer (General Counsel) | Open-market sale | −475 | $9.29 | $4,413 |
| Mar 16, 2026 | Houghton Adam Officer (Chief Business Officer) | Open-market sale | −699 | $9.29 | $6,494 |
Peers
Compare boardsOrganizations in the same sector, closest in location and size first.
Questions about Upstream Bio Inc.
Who is the CEO of Upstream Bio Inc.?
Everett Rand Sutherland has been Upstream Bio Inc.'s Chief Executive Officer since October 2024.
How many directors are on Upstream Bio Inc.'s board?
Upstream Bio Inc.'s board has 7 directors: Daniella Beckman, Erez Chimovits, Everett Rand Sutherland, Harold Edward Fleming, Liam Ratcliffe, Marcella K. Ruddy and Ronald C. Renaud Jr.
Are Upstream Bio Inc. insiders buying or selling shares?
Over the last 12 months, Upstream Bio Inc. insiders made no open-market purchases and sold $104,796 of shares in 15 sales on the open market, as reported to the SEC on Forms 4 and 5.
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