OnKure Therapeutics Inc.

Last updated September 27, 2026

Organization details

Legal name
OnKure Therapeutics Inc.
Former names
Reneo Pharmaceuticals, Inc.
Ownership
Public
Status
Active
SIC code
2834 — Pharmaceutical Preparations
Jurisdiction of incorporation
Delaware
Headquarters city
Boulder
Headquarters state / province
Colorado
Headquarters country
United States
Fiscal year end
December
Ticker symbol
OKUR
Primary stock exchange
Nasdaq

Identifiers

SEC CIK
0001637715
EIN
47-2309515

Board of directors

Chief executives

Nicholas A. Saccomano · President and CEO
Dates unknown

Director election results

Annual meeting of June 3, 2026. Support is votes for as a share of votes for and against (or withheld). Below 80% is a clear protest.

Board connections

9 of this board's directors also sit on 16 other boards.

Network of OnKure Therapeutics Inc.'s board connections Spruce Biosciences Inc. Spruce Biosciences Inc... Addex Therapeutics Ltd Addex Therapeutics Ltd Climb Bio Inc. Climb Bio Inc. Disc Medicine Inc. Disc Medicine Inc. Enliven Therapeutics Inc. Enliven Therapeutics I... MBX Biosciences Inc. MBX Biosciences Inc. Mirum Pharmaceuticals Inc. Mirum Pharmaceuticals... MoonLake Immunotherapeutics MoonLake Immunotherape... Q32 Bio Inc. Q32 Bio Inc. Rainier Acquisition Corporation Rainier Acquisition Co... Rhythm Pharmaceuticals Inc. Rhythm Pharmaceuticals... Sagimet Biosciences Inc. Sagimet Biosciences In... Senti Biosciences Holdings Inc. Senti Biosciences Hold... Travere Therapeutics Inc. Travere Therapeutics I... Trevi Therapeutics Inc. Trevi Therapeutics Inc... Upstream Bio Inc. Upstream Bio Inc. Andrew John Phillips Andrew John Phillips Bali Muralidhar Bali Muralidhar Edward T. Mathers Edward T. Mathers Eric M. Dube Eric M. Dube Isaac Manke Isaac Manke Liam Ratcliffe Liam Ratcliffe Michael G. Grey Michael G. Grey Niall O'Donnell Niall O'Donnell Paul W. Hoelscher Paul W. Hoelscher OnKure Therapeutics Inc.
Shared director Other board Same sector

Insider trades

All notable trades →

From SEC Forms 4 and 5. Open-market purchases and sales are highlighted; grants, option exercises and shares withheld for tax are routine.

Bought, last 12 months
$0
0 purchases by 0 insiders
Sold, last 12 months
$5,634
8 sales by 2 insiders
Date Insider Transaction Shares Price Value
Sep 21, 2026 Leverone Jason A. Officer (Chief Financial Officer) Open-market sale −302 $2.97 $898
Sep 21, 2026 Nicholas A. Saccomano Director, Officer (President and CEO) Open-market sale −87 $2.97 $259
Jun 22, 2026 Nicholas A. Saccomano Director, Officer (President and CEO) Open-market sale −86 $4.40 $378
Jun 22, 2026 Leverone Jason A. Officer (Chief Financial Officer) Open-market sale −303 $4.40 $1,333
Mar 23, 2026 Nicholas A. Saccomano Director, Officer (President and CEO) Open-market sale −86 $4.16 $358
Mar 23, 2026 Leverone Jason A. Officer (Chief Financial Officer) Open-market sale −301 $4.16 $1,252
Dec 31, 2025 Edward T. Mathers Director Grant or award +3,911 — —
Dec 31, 2025 Isaac Manke Director Grant or award +5,258 — —
Dec 22, 2025 Nicholas A. Saccomano Director, Officer (President and CEO) Open-market sale −87 $2.97 $258
Dec 22, 2025 Leverone Jason A. Officer (Chief Financial Officer) Open-market sale −302 $2.97 $897
Sep 30, 2025 Edward T. Mathers Director Grant or award +4,125 — —
Sep 30, 2025 Isaac Manke Director Grant or award +5,545 — —
Sep 22, 2025 Nicholas A. Saccomano Director, Officer (President and CEO) Open-market sale −88 $2.62 $231
Sep 22, 2025 Leverone Jason A. Officer (Chief Financial Officer) Open-market sale −303 $2.62 $794
Jun 30, 2025 Edward T. Mathers Director Grant or award +4,694 — —

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