Xilio Therapeutics Inc.

Last updated September 27, 2026

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Organization details

Legal name: Xilio Therapeutics Inc.
Ownership: Public
Status: Active
Sector (GICS): Health Care
SIC code: 2834 — Pharmaceutical Preparations
Jurisdiction of incorporation: Delaware
Headquarters city: Waltham
Headquarters state / province: Massachusetts
Headquarters country: United States
Fiscal year end: December
Ticker symbol: XLO
Primary stock exchange: Nasdaq

Identifiers

SEC CIK: 0001840233
EIN: 85-1623397

Board of directors

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Akintunde Olatokumbo Bello · Director
Since 2025
Aoife Brennan · Director
Since 2024
Cheryl R. Blanchard · Director
Since 2026
Christina Rossi · Director
Since 2023
Daniel J. Curran · Director
Since 2024
James Samuel Shannon · Director
Since 2024
Paul J. Clancy · Director
Since 2023
Rene Russo · Director · PRESIDENT AND CEO
Since 2023
Robert W. Ross · Director
Since 2023
Sara Bonstein · Director
Since 2023
Tomas J. Heyman · Director
Since 2023
Yuan Xu · Director
Since 2023

Chief executives

Rene Russo · CEO

Dates unknown

Director election results

Annual meeting of June 10, 2026. Support is votes for as a share of votes for and against (or withheld). Below 80% is a clear protest.

Board connections

10 of this board's directors also sit on 16 other boards. 16 are in the same sector.

Shared director Other board Same sector

ALX Oncology Holdings Inc. Same sector
via Daniel J. Curran
Anika Therapeutics Inc. Same sector
via Cheryl R. Blanchard
CG Oncology Inc. Same sector
via Christina Rossi
Climb Bio Inc. Same sector
via Aoife Brennan
Dare Bioscience Inc. Same sector
via Cheryl R. Blanchard
Exelixis Inc. Same sector
via Tomas J. Heyman
Fate Therapeutics Inc. Same sector
via Yuan Xu
Incyte Corp. Same sector
via Paul J. Clancy
Invivyd Inc. Same sector
via Tomas J. Heyman
Kyntra Bio Inc. Same sector
via Aoife Brennan
Latigo Biotherapeutics Inc. Same sector
via Sara Bonstein
Legend Biotech Corporation Same sector
via Tomas J. Heyman
MannKind Corporation Same sector
via James Samuel Shannon
Obsidian Therapeutics Inc. Same sector
via Robert W. Ross
ProQR Therapeutics N.V. Same sector
via James Samuel Shannon
Sionna Therapeutics Inc. Same sector
via Paul J. Clancy

Insider trades

All notable trades →

From SEC Forms 4 and 5. Open-market purchases and sales are highlighted; grants, option exercises and shares withheld for tax are routine.

Bought, last 12 months: $0; 0 purchases by 0 insiders
Sold, last 12 months: $5,668; 2 sales by 2 insiders

Date	Insider	Transaction	Shares	Price	Value
Mar 26, 2026	James Samuel Shannon Director	Open-market purchase	+5,000	$8.79	$43,950
Jan 2, 2026	Brennan Kevin M. Officer (SVP, FINANCE AND ACCOUNTING)	Open-market sale	−1,826	$0.64	$1,169
Jan 2, 2026	Frankenfield Christopher James Officer (Chief Financial Officer)	Open-market sale	−7,030	$0.64	$4,499
Jan 1, 2026	Luptakova Katarina Officer (CHIEF MEDICAL OFFICER)	Option exercise	+16,625	—	—
Jan 1, 2026	Brennan Kevin M. Officer (SVP, FINANCE AND ACCOUNTING)	Option exercise	+5,000	—	—
Jan 1, 2026	Frankenfield Christopher James Officer (Chief Financial Officer)	Option exercise	+19,375	—	—
Jan 1, 2026	Rene Russo Director, Officer (PRESIDENT AND CEO)	Option exercise	+44,250	—	—
Jun 17, 2025	James Samuel Shannon Director	Open-market purchase	+25,000	$0.69	$17,250
Jun 16, 2025	James Samuel Shannon Director	Open-market purchase	+45,000	$0.69	$31,050
Jun 16, 2025	Rene Russo Director, Officer (PRESIDENT AND CEO)	Open-market purchase	+36,289	$0.68	$24,677
Jan 2, 2025	Frankenfield Christopher James Officer (Chief Financial Officer)	Open-market sale	−6,954	$0.98	$6,815
Jan 2, 2025	Brennan Kevin M. Officer (SVP, FINANCE AND ACCOUNTING)	Open-market sale	−1,803	$0.98	$1,767
Jan 1, 2025	Frankenfield Christopher James Officer (Chief Financial Officer)	Option exercise	+19,375	—	—
Jan 1, 2025	Luptakova Katarina Officer (CHIEF MEDICAL OFFICER)	Option exercise	+16,625	—	—
Jan 1, 2025	Rene Russo Director, Officer (PRESIDENT AND CEO)	Option exercise	+44,250	—	—

Peers

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Questions about Xilio Therapeutics Inc.

Who is the CEO of Xilio Therapeutics Inc.?

Rene Russo is Xilio Therapeutics Inc.'s CEO.

How many directors are on Xilio Therapeutics Inc.'s board?

Xilio Therapeutics Inc.'s board has 12 directors: Akintunde Olatokumbo Bello, Aoife Brennan, Cheryl R. Blanchard, Christina Rossi, Daniel J. Curran, James Samuel Shannon, Paul J. Clancy, Rene Russo, Robert W. Ross, Sara Bonstein and 2 others.

Are Xilio Therapeutics Inc. insiders buying or selling shares?

Over the last 12 months, Xilio Therapeutics Inc. insiders made no open-market purchases and sold $5,668 of shares in 2 sales on the open market, as reported to the SEC on Forms 4 and 5.

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